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교수소개

교수소개 - 화학공학부

  • 교수 Systems Biotechnology
  • 이동엽 홈페이지 바로가기
    Lab 공정설계 및 시스템공학 연구실

관심분야

- 시스템생명공학
- 합성생물학
- 다지털트윈
- 마이크로바이옴 생균치료제
- 공정시스템

학력

  • 한국과학기술원 박사
  • 한국과학기술원 석사
  • 연세대학교 학사

학술지 논문

  • (2026)  A community reconstruction of Chinese hamster metabolism and structural systems biology elucidate metabolic rewiring in lactate-free CHO cells.  CELL SYSTEMS.  17, 
  • (2026)  Exploring the effect of prolonged passaging on production stability in CHO cells by leveraging eXplainable AI-driven flux balance analysis.  NPJ SYSTEMS BIOLOGY AND APPLICATIONS.  12, 
  • (2025)  Evolution-aided enhancement of β-glucosidase activity for improved conversion of isoflavone glucosides to aglycones by Lactobacillus gasseri.  FOOD CHEMISTRY.  493,  0
  • (2025)  Systematic identification of genomic hotspots for high-yield protein production in CHO cells.  NEW BIOTECHNOLOGY.  88, 
  • (2025)  Combining site-specific gut microbiome and mycobiome profiling with clinical indicators for effective management of pediatric Crohn's disease.  ISCIENCE.  28,  8
  • (2025)  Deciphering dynamic antibiotics-microbiomemetabolome interactions in preterm infants using systems biology.  ISCIENCE.  28,  8
  • (2025)  AutoML-Driven Soft Sensors for Real-Time Monitoring of Amino Acids in Mammalian Perfusion Cultures.  BIOTECHNOLOGY AND BIOENGINEERING.  122,  11
  • (2025)  Genome-scale metabolic model-guided systematic framework for designing customized live biotherapeutic products.  NPJ SYSTEMS BIOLOGY AND APPLICATIONS.  11,  1
  • (2025)  A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis.  JOURNAL OF BIOTECHNOLOGY.  401, 
  • (2025)  Comparative Analysis of Codon Optimization Tools: Advancing toward a Multi-Criteria Framework for Synthetic Gene Design.  JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY.  35, 
  • (2025)  Characterization and design of dipeptide media formulation for scalable therapeutic production.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  109,  1
  • (2024)  Kinetics-based inference of environment-dependent microbial interactions and their dynamic variation.  MSYSTEMS.  9,  5
  • (2024)  Driving towards digital biomanufacturing by OHO genome-scale models.  TRENDS IN BIOTECHNOLOGY.  42,  9
  • (2024)  Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing.  BIOTECHNOLOGY ADVANCES.  71, 
  • (2024)  Evaluating oleaginous yeasts for enhanced microbial lipid production using sweetwater as a sustainable feedstock.  MICROBIAL CELL FACTORIES.  23,  1
  • (2024)  Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  108,  1
  • (2023)  Data-driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins.  BIOTECHNOLOGY AND BIOENGINEERING.  120,  9
  • (2023)  Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided analyses.  BIOTECHNOLOGY JOURNAL.  18,  12
  • (2023)  Mitigating biomass composition uncertainties in flux balance analysis using ensemble representations.  COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL.  21,  -
  • (2023)  Genome-scale metabolic modeling and <i>in silico</i> analysis of opportunistic skin pathogen <i>Cutibacterium acnes</i>.  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.  13,  -

학술회의논문

  • (2022)  Characterizing basal and feed media effects on mammalian cell cultures by systems engineering approaches.  Part of special issue:13th IFAC Symposium on Dynamics and Control of Process Systems.  대한민국