Translational Nanobioscience
Our lab is focused on characterizing the interactions of biomacromolecules and nanomaterials with biological systems, and translating scientific insights into engineered solutions to address outstanding needs in medicine, biotechnology, and agriculture. Key research areas include biosensor development, interfacial science, and biophysics. We also develop pharmaceutical drugs and nanomedicines for infectious disease, cancer, and immunology applications, especially lipid nanoparticle technologies. Current projects include:
1. Lipid Nanoparticle Technology for Pharmaceutical Drug and Vaccine Delivery 2. Label-Free Biosensors for Medicine and Biotechnology
3. Peptide and Protein Engineering
4. Lipid Membrane Biotechnology
5. Antimicrobial Lipids: Biophysical Mechanisms and Biological Activities
6. STEM Education and Innovation
Education
Ph.D. in Materials Science and Engineering, Nanyang Technological University (2015) B.S. in Chemistry (summa cum laude), University of Florida (2010)
(2023)
Interfacial approach to fabricate covalently and noncovalently attached inverse-phosphocholine supported lipid bilayers on TiO2 and SiO2 surfaces.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY.
128,
-
(2023)
pH-Modulated Nanoarchitectonics for Enhancement of Multivalency-Induced Vesicle Shape Deformation at Receptor-Presenting Lipid Membrane Interfaces.
LANGMUIR.
39,
23
(2023)
Unraveling Membrane-Disruptive Properties of Sodium Lauroyl Lactylate and Its Hydrolytic Products: A QCM-D and EIS Study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
24,
11
(2023)
Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy.
NATURE MATERIALS.
22,
5
(2023)
Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy.
NANOMATERIALS.
13,
5
(2022)
Unraveling How Cholesterol Affects Multivalency-Induced Membrane Deformation of Sub-100 nm Lipid Vesicles.
LANGMUIR.
38,
51
(2022)
Antimicrobial monoglycerides for swine and poultry applications.
Frontiers in Animal Science.
3,
N.A
(2022)
Facile and scalable fabrication of exosome-mimicking nanovesicles through PEGylated lipid detergent-aided cell extrusion.
NANOSCALE.
14,
44
(2022)
Nanoarchitectonics-based model membrane platforms for probing membrane-disruptive interactions of odd-chain antimicrobial lipids.
NANO CONVERGENCE.
9,
1
(2022)
Biophysical Characterization of LTX-315 Anticancer Peptide Interactions with Model Membrane Platforms: Effect of Membrane Surface Charge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
23,
18
(2022)
Modulating noncovalent and covalent forces to control inverse phosphocholine lipid self-assembly on inorganic surfaces: Nanoarchitectonic design principles.
APPLIED MATERIALS TODAY.
29,
N.A
(2022)
Distinct Binding Properties of Neutravidin and Streptavidin Proteins to Biotinylated Supported Lipid Bilayers: Implications for Sensor Functionalization.
SENSORS.
22,
14
(2022)
Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective.
ADVANCED FUNCTIONAL MATERIALS.
32,
37
(2022)
Mechanistic Evaluation of Antimicrobial Lipid Interactions with Tethered Lipid Bilayers by Electrochemical Impedance Spectroscopy.
SENSORS.
22,
10
(2022)
Lipid coating technology: A potential solution to address the problem of sticky containers and vanishing drugs.
VIEW.
3,
3
Publications
(2023)
Quartz Crystal Microbalance-Dissipation Technique for Tracking Dynamic Biomacromolecular Interactions.
Springer Nature.
Solo
Honors / Awards
ACS Nano Junior Fellow, 2017 American Liver Foundation Herman Lopata Memorial Hepatitis Postdoctoral Research Fellowship Award, 2016 – 2017 Nanyang Technological University MSE Doctorate Technopreneur Award, 2016 Nano Korea Grand Prize Award, 2013 Nanyang President’s Graduate Scholar, 2011 – 2015 Harvard-MIT HST Division Martinos Scholar, 2011 National Science Foundation Graduate Research Fellowship, 2010 Harvard-MIT HST Division MEMP Graduate Fellowship, 2010 University of Florida Department of Chemistry Crow Award, 2010 National Science Foundation CPIMA SURE Fellowship, 2009 Phi Beta Kappa, 2008 UF-HHMI Science for Life Extramural Research Award, 2008 Arnold and Mabel Beckman Foundation Beckman Scholars Fellowship, 2007 University of Florida John V. Lombardi Scholarship, 2006 U.S. Department of Education Robert C. Byrd Honors Scholarship, 2006
