Park Jae-hyung, a professor of Chemical Engineering, increases the effectiveness of cancer treatment with nano bubbles
Park Jae-hyung, a professor in the Department of Chemical Engineering, increases the effectiveness of cancer treatment with cancer-causing nano bubbles.
The Korea Research Foundation announced on September 9 that a research team led by Professor Park Jae-hyung of Sungkyunkwan University has developed a technology that can cause rupture of cancer cell membranes using nano bubbles that radiate ultrasonic waves.
The "necroptosis" reaction, in which cancer cells destroy cell membranes and kill themselves, does not need to involve decomposing enzymes, which can reduce damage to immunogenic substances to a minimum.
However, there is a limit to the development of treatments for most cancer cells due to low levels of protein that causes necrotosis.
The research team succeeded in inducing similar necrotosis reactions by using physical stimuli, not proteins.
The principle is to design a polymer that explodes cancer cells using bubbles and then warm up the ultrasound, and the liquid inside the polymer turns into a gas and causes the volume to expand and destroy cell membranes.
The team observed that the structure of cancer cells collapses by nano bubbles once ultrasonic waves are warmed through a focal microscope.
In particular, it has been confirmed that treatment of nanofluids in colon cancer cells does not damage immune-induced substances unlike treatment of active oxygen.
According to the research team's research on mice that caused lung cancer, the weight of tumors decreased by 97 percent compared to when immuno-tube inhibitors were administered alone.
The findings were published in the online edition of the international journal Advanced Materials on Thursday.