Professor Kim Jae-Yoon of Chemical Engineering, Development of Adhesive Hydrogel Patch for Transdermal Drug Delivery
- 공과대학
- Hit4505
- 2021-01-24
Research team of Professor Kim Jae-yoon of the Department of Chemical Engineering/Polymer Engineering, Development of Adhesive Hydrogel Patch for Transdermal Drug Delivery
Professor Kim Jae-yoon's research team at the Department of Chemical Engineering/Polymer Engineering (first author Jeong Hu-yeon), has developed an adhesive hydrogel patch for transdermal drug delivery with excellent skin adhesion and mechanical strength.
Hydrogel is a hydrophilic polymer three-dimensional network containing more than 90% of water and is widely used as a drug transfer material for delivering various physiological active drugs. However, conventional hydrogels have low adhesion to the skin, which limits the delivery of drugs from the skin for a long time, and hydrogels with adhesion have problems of tearing easily due to reduced mechanical strength.
The team produced adhesive hydrogels, including poly-dopamine, which is well known as mussel adhesives, and porous silica nanoparticles with pore sizes of tens of nanometers. Due to the high interaction with the macromolecular chain, which forms hydrogels with a large surface area of porous silica nanoparticles, it was able to implement hydrogels with excellent skin adhesion while maintaining mechanical strength. Additional application of porous silica nanoparticles to the intersection between the adhesive hydrogel and the skin could further increase adhesion.
If the adhesive hydrogel patch, which was made by putting the model drug in the pores of porous silica nanoparticles, was attached to the pig skin, the drug was slowly delivered from the skin surface to the skin. Even if removed from the skin, hydrogel residue was removed without leaving any residue on the skin, and the inflammatory reaction of the attached skin area was minimal, confirming that the hydrogel itself was highly biocompatible.
Professor Kim Jae-yoon explained, "In the future, it will be able to be applied to develop patches for transdermal drug delivery that can deliver drugs while maintaining a wet environment for various skin diseases."
The results of this study were selected as the Frontispiece paper, an international journal of materials science, and was conducted with support from the Ministry of Science and ICT and the Korea Research Foundation for mid-sized researchers and the Korea Forest Service and Forestry Research Institute.
※ Name of the paper: Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery, Adhesive Hydrogel Patch for Transdermal Drug Delivery with Excellent Strength and Skin Adhesiveness