Sewing DNA by… ‘Constructing a Novel DNA Sewing Nanoarchitecture’
- Engineering
- Hit5521
- 2015-12-08
Sewing DNA Sewing DNA by… ‘Constructing a Novel DNA Sewing Nanoarchitecture’
Developed by Prof. Um, Soong Ho from Sungkyunkwan University, Published by ‘Scientific Reports’online in Dec. 4th. http://www.nature.com/articles/srep17722
□ With the advent of nanotechnology, a nucleic acid, which is recognized as a genetic code, is now designed and manufactured into several nanoscaled shapes including line, net, box, and even a variety of imoticons. It is furthermore developed into various nanostructures. Interestingly, DNA nanoarchitectures have been exploited for biomedical uses containing an environment-responsive drug delivery system and an oncogene- or diseases-specific probe for in vivo signal monitoring. Two representative methodologies for creating new DNA nanostructures are proposed; First, one long-stranded DNA which is predictably programmed is clipped by small fragment DNAs termed as staple DNAs. Second, small DNA blocks which is similar to a unit cell of a crystal structure are crosslinked by a ligation-enzymatic activity. The former, which is more popular about the DNA nanotechnology, suffers from a lower product yield and unstability. The latter is relatively ignored eventhough it has much merits of both higher productivity and longer thermodynamic stability. This study may offer a higher preference to DNA sewing technology and then present novel DNA nanostructures for live-cell signal captures and amplification.
□ Prof. Um’s research team from Sungkyunkwan University has developed a DNA sewing architecture. The research team is now constructing DNA nanotechnology very easily. using this sewing technology. It can synthesize a few nanoscaled architecture very precisely, which can be applied into selectively interacting with its surroundings with respect to its varying sizes.